A lecture note on Medical biochemistry integrates and summarizes the. Mutations of APP on chromosome 21, Presenilin 1, and Presenilin 2 genes are the causes of early onset Alzheimer disease. professor of Biochemistry, Medical Faculty, Addis Ababa University and Ato. It’s due to amyloid deposits on β cells of the pancreas, leading to increase in insulin resistance.Į) Hypertrophic cardiomyopathy is a diastolic dysfunction, which is due to mutation of the β-myosin heavy chain. ni hoga jismey ye na poochein jayein -metabolism of VLDL LDL HDL Chylomicrons -sb apki finger. With less LDL receptors, there will be high concentration of LDL in serum, which will lead to atherosclerosis to myocardial infarction, and eventually death to people in their teenage years.ĭ) Diabetes mellitus, type 2 has a strong polygenic genetic predisposition, more than type 1. For better understanding you can watch Dr Najeeb lectures. Pylori infection.Ĭ) Familial hypercholesterolemia is an autosomal dominant disease in which there are decreased number of LDL receptors. The late onset of Alzheimer disease is due to mutation on chromosome 19 of apolipoprotein E4 gene, which is the cause of senile plaques.ī) Peptic ulcer disease is strongly associated with H. APP is located on chromosome 21 therefore, having an extra chromosome 21 will multiply the chances of Alzheimer disease, usually around 35-years-old. Down syndrome patients have three 21 chromosomes. – APP (Amyloid precursor protein) gene on chromosome 21ĭown syndrome patients have early onset of Alzheimer disease. There are three sites of mutations for the early onset, which can manifest the disease: There is early onset dementia, less than 60-years-old, and there is late onset dementia, greater than 60-years-old.
The illness has a very strong genetic association therefore, at least 20% of the patients have family history of the disease. First Aid classified the disease in the pathology section of the Neurology chapter. The correct answer is ( A), Alzheimer Dementia.Ĭortical atrophy in Alzheimer disease, leads to dilation ofĪlzheimer disease is a type of dementia in which the patient gradually looses memory. Currently he is asymptomatic however, when the patient gets older which of the following will he most likely suffer from? director of this college who was later joined by Dr.Najeeb Khan and. A 29-year-old male participates in a clinical research project and found to be homozygous for the apolipoprotein E-4 allele. The teaching program at AIIMS Jodhpur is based on traditional lectures and modern e.